DSSR started displaying error messages and even refusing to load on some PCs in December 2014. Even my garden observatory PC was affected even though no code had changed. I can only surmise that some Windows update had upset DSSR. Most errors were easy to fix and DSSR 4.10 now has a debug mode and improved error logging that help me fix any future errors.
First off, check that your Windows text size in your Windows display settings is set to the default 100%. DSSR may not start and will certainly not autoguide if it is not 100%.
Next, start DSSR and click the I Agree (debug) button. You will then see a series of boxes with a letter code like A, B etc. Click on the OK buttons and remember the last code displayed before DSSR crashed. If you get as far as the main DSSR window make sure logging is running and then write down exactly what you are trying when you see the error. Close DSSR.
You can then use my software support group to post your results together with the relevant log which should be in your capture folder. I will get back to you in a matter of minutes (or days) with a fix.