We just had some problems with new users which was tracked down to the Windows text size which can be altered in Control Panel>Appearance and Personalization>Display.
Any setting other that 100% may prevent DSSR from starting and will certainly prevent it from autoguiding.
Apparently, a lot of laptops are now shipped with 125% text size out of the box and these need to be changed to 100% before running DSSR. This will also solve problems in other software with text not displaying correctly.
If you have trouble reading text at 100% then use a lower screen resolution which will not affect DSSR.